From Ryan Hughes:
The first thing that has to be done is install UnixODBC.
Add the directory where the libodbc.so file (supplied by UnixODBC) is stored (in my case /usr/lib) to your PATH.
Then install the iSeriesODBC driver by following the iSeries ODBC Installation Guide.i.
Finally set up your data sources and you should be good to go.
On a side note, I did a test with the LS Connectors using the lctest tool (/opt/lotus/notes/linux/latest/lctest) and it seemed to work as well. The connectors would probably be the preferred way to go for data access (JDBC is a good option as well) but I needed LS:DO for some existing applications.